| Primary Identifier | MGI:6315230 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Stxbp5 |
| Strain of Origin | (C57BL/6 x SJL)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 endonuclease-mediated genome editing was used to create an amino acid substitution at position 437 altering asparagine to serine (N437S; AAT to AGC) in exon 13 of the gene. The mutation is located in the WD40 repeat domain, which is involved in regulation of exocytosis in multiple cell types. The orthologous human variant N436S (SNP rs1039084) is associated with decreased thrombosis. |
