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Allele : Smpdl3a<em2(IMPC)Tcp> sphingomyelin phosphodiesterase, acid-like 3A; endonuclease-mediated mutation 2, The Centre for Phenogenomics

Primary Identifier  MGI:6316217 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Smpdl3a
Strain of Origin  C57BL/6NCrl Is Recombinase  false
Is Wild Type  false Project Collection  IMPC
molecularNote  This allele from project TCPR0788 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with four guide RNAs having spacer sequences of GAGAGCTGTGCTTAAACTCG and ACGTGCCAAAACTGCCCTGT targeting the 5' side and CACTGGGCAATCATGACTAC and TGTCAGAGTTATGACAGTGG targeting the 3' side of exons ENSMUSE00000098735, ENSMUSE00000724134, and ENSMUSE00001304146 resulting in a 1647-bp deletion of Chr10 from 57800909 to 57802555 and a 2-bp deletion of Chr10: 57802634 to 57802635 (GRCm38).
  • mutations:
  • Intragenic deletion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories