| Primary Identifier | MGI:6342430 | Allele Type | Endonuclease-mediated |
| Attribute String | Hypomorph, Modified isoform(s) | Gene | Cwc27 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false | Project Collection | Lexicon |
| molecularNote | An eight bp deletion in exon 11 (AAAAGTGG) was generated by CRISPR/Cas9 mutagenesis. This resulted in a shift of the reading frame. RT-PCR in mouse retina RNA found that Cwc27 mRNA level in homozygous mice was 45% of that in control mice, suggesting that this allele is a hypomorph. |
