| Primary Identifier | MGI:6343542 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Gm26878 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| description | Although Gm26878 is located in the mouse region syntenic with the human FOXF1 upstream enhancer, RT-qPCR analysis presented in J:250380 did not reveal any significant differences in Foxf1 expression in the lungs of E18.5 homozygous embryos relative to wild-type controls. These data indicate that the regulation of FOXF1 expression differs between human and mouse. |
| molecularNote | The entire gene was deleted via CRISPR/Cas9 mutagenesis. Sanger sequencing confirmed the presence of a single 2396-bp interval deletion spanning Gm26878 in G1 progeny generated from founder M1. |
