| Primary Identifier | MGI:6356400 | Allele Type | Targeted |
| Gene | Nr3c1 | Transmission | Germline |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A loxP_2272 site was inserted upstream of exon 2, and an FRT flanked neo cassette, a loxP site, an inverted mutated exon 2 with two serine to alanine mutations (S152A and S284A), a loxP_2272 site and a loxP site were inserted downstream of exon 2. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed the wild-type exon 2 and flipped the mutant exon 2 into the correct orientation. This allele lacks the BDNF-dependent GR-phosphorylation sites in exon 2. |
