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Allele : Cd274<em1Okat> CD274 antigen; endonuclease-mediated mutation 1, Taku Okazaki

Primary Identifier	MGI:6356539	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Cd274
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR mediated recombination introduced a single nucleotide insertion of a G resulting in the conversion of Y56 to a premature stop codon.

mutations:
Nucleotide substitutions

synonyms:
Cd274-,
Cd274-

earliestPublication:
Sugiura D, et al. (2019) Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science 364(6440):558-566

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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