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Allele : Gt(ROSA)26Sor<tm1(CAG-Vps4b*)1Hjug> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Harald Junge
Primary Identifier  MGI:6357993 Allele Type  Targeted
Attribute String  Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (C57BL/6J x 129X1/SvJ)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A dominant-negative isoform of mouse Vps4b (Vps4b-EQ) cDNA with MycHis tag and bovine growth hormone polyadenylation sequence were placed under the control of a CAG promoter and lox-stop-lox sequence. VPS4b EQ has a modified E235Q in the encoded protein, which strongly inhibited signalling activity.
  • mutations:
  • Insertion
  • synonyms:
  • VPS4 EQ,
  • VPS4 EQ
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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