| Primary Identifier | MGI:6391112 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Ttc29 |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 12 sequence chr8:78333554-78333613 (GRCm38/mm10) was targeted by an sgRNA using CRISPR/Cas9 technology. A single C nucleotide deletion (c.1128del) results in a frameshift after tyrosine 376 and a premature stop codon mutation shortly after, that is similar the p.Tyr369* mutation found in patients suffering from multiple morphological abnormalities of the flagella (MMAF; a severe type of asthenoteratospermia). In spermatozoa of homozygous mice, mRNA levels from this allele are significantly reduced and peptides near absent. |
