| First Author | Castilla-Ortega E | Year | 2012 |
| Journal | Behav Brain Res | Volume | 232 |
| Issue | 2 | Pages | 400-5 |
| PubMed ID | 22537775 | Mgi Jnum | J:185421 |
| Mgi Id | MGI:5428772 | Doi | 10.1016/j.bbr.2012.04.018 |
| Citation | Castilla-Ortega E, et al. (2012) Hippocampal c-Fos activation in normal and LPA(1)-null mice after two object recognition tasks with different memory demands. Behav Brain Res 232(2):400-5 |
| abstractText | Normal and LPA(1)-null mice, that have well reported hippocampal deficits, were assessed in an episodic-like what-when-where memory task or in a comparable task designed to test memory for familiar objects and locations by discriminating them from novels. Both genotypes performed the novelty recognition task but failed to learn the what-when-where task. However, normal mice showed what-when memory that was impaired in nulls. Each task elicited a different pattern of c-Fos expression. In normal mice, the what-when-where task induced more hippocampal c-Fos activation in the CA1 area than the novelty-based task, correlating with the what-when memory. LPA(1)-null mice displayed a basal c-Fos hyperactivity in the hippocampus and in the medial prefrontal cortex, which was regulated differently by the two behavioural tasks employed. Both tasks were matched in exploratory behaviour and c-Fos activation in stress-related brain areas for both genotypes. This study shows that the what-when-where memory task differs from a comparable novelty-based task in both the learning demands and the neuronal correlates. Moreover, results also stress the role of the LPA(1) receptor in hippocampal functioning. |
