| First Author | Krištić J | Year | 2018 |
| Journal | Nat Chem Biol | Volume | 14 |
| Issue | 5 | Pages | 516-524 |
| PubMed ID | 29632412 | Mgi Jnum | J:276361 |
| Mgi Id | MGI:6313878 | Doi | 10.1038/s41589-018-0034-3 |
| Citation | Kristic J, et al. (2018) Profiling and genetic control of the murine immunoglobulin G glycome. Nat Chem Biol 14(5):516-524 |
| abstractText | Immunoglobulin G (IgG) glycosylation is essential for function of the immune system, but the genetic and environmental factors that underlie its inter-individual variability are not well defined. The Collaborative Cross (CC) genetic resource harnesses over 90% of the common genetic variation of the mouse. By analyzing the IgG glycome composition of 95 CC strains, we made several important observations: (i) glycome variation between mouse strains was higher than between individual humans, despite all mice having the same environmental influences; (ii) five genetic loci were found to be associated with murine IgG glycosylation; (iii) variants outside traditional glycosylation site motifs affected glycome variation; (iv) bisecting N-acetylglucosamine (GlcNAc) was produced by several strains although most previous studies have reported the absence of glycans containing the bisecting GlcNAc on murine IgGs; and (v) common laboratory mouse strains are not optimal animal models for studying effects of glycosylation on IgG function. |
