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Allele : Tg(Prnp-APPSweOsa)#Luk transgene insertion, Luka Kulic

Primary Identifier	MGI:6378818	Allele Type	Transgenic
Attribute String	Humanized sequence, Inserted expressed sequence	Gene	Tg(Prnp-APPSweOsa)#Luk
Strain of Origin	(C57BL/6 x DBA/2)F1	Is Recombinase	false
Is Wild Type	false

molecularNote

The cDNA for isoform 695 of the human APP gene, engineered to contain the Swedish K670N and M671L and Osaka E693 deletion mutations, was placed under the control of the mouse prion protein promoter.

mutations:
Insertion

synonyms:
E22DeltaAbeta,
E22DeltaAbeta

earliestPublication:
Kulic L, et al. (2012) Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Abeta APP mutation. Transl Psychiatry 2:e183

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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