| Primary Identifier | MGI:6367794 | Allele Type | Targeted |
| Attribute String | Dominant negative | Gene | Prph2 |
| Inheritance Mode | Dominant | Transmission | Germline |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Two point mutations were introduced to exon 1 of the gene. The first was a silent C>G, to eliminate a Hinf1 restriction site to aid in genotyping, and the second was the pathogenic A>G, to introduce the p.Y141C substitution in the encoded protein. An frt site flanked neomycin selection cassette was removed via Flp-mediated recombination. |
