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Allele : Top6bl<em1Bdm> TOP6B like initiator of meiotic double strand breaks; endonuclease-mediated mutation 1, Bernard de Massy

Primary Identifier	MGI:6367799	Allele Type	Endonuclease-mediated
Attribute String	Not Specified	Gene	Top6bl
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

Using the CRISPRCas9 technology, donor oligos were designed to change the W562 codon TGG (W) to GCG (A) in the mouse Gm960 gene, and to introduce a silentmutation (A to G) to generate a PstI restriction site.

mutations:
Nucleotide substitutions

synonyms:
Top6bl<em1(W562A)BdM>,
Top6bl<em1(W562A)BdM>

earliestPublication:
Nore A, et al. (2022) TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nat Commun 13(1):7048

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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