| Primary Identifier | MGI:6388456 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Ngf |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The human NGF coding sequence with an arginine to tryptophan substitution at amino acid 100 (R100W) and loxP flanked NeoR/KanR cassette and PGK promoter replaced the mouse Ngf coding sequence via homologous recombination. The C to T transition at position 661 resulting in the R100W mutation is seen in patients with Hereditary Sensory and Autonomic Neuropathy type 5. |
