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Allele : Iqsec2<em1Csbg> IQ motif and Sec7 domain 2; endonuclease-mediated mutation 1, Cheryl Shoubridge

Primary Identifier	MGI:6392156	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Iqsec2
Strain of Origin	C57BL/6NHsd	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR-targeting removed exon 3 in both main isoforms. Exons 2, 4, and 5 are not affected.

mutations:
Intragenic deletion

earliestPublication:
Hinze SJ, et al. (2017) Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis. Transl Psychiatry 7(5):e1110

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

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