| First Author | Undi RB | Year | 2023 |
| Journal | J Virol | Volume | 97 |
| Issue | 11 | Pages | e0119423 |
| PubMed ID | 37861336 | Mgi Jnum | J:354746 |
| Mgi Id | MGI:7736423 | Doi | 10.1128/jvi.01194-23 |
| Citation | Undi RB, et al. (2023) Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network. J Virol 97(11):e0119423 |
| abstractText | Severe COVID-19 and post-acute sequelae often afflict patients with underlying co-morbidities. There is a pressing need for highly effective treatment, particularly in light of the emergence of SARS-CoV-2 variants. In a previous study, we demonstrated that DCLK1, a protein associated with cancer stem cells, is highly expressed in the lungs of COVID-19 patients and enhances viral production and hyperinflammatory responses. In this study, we report the pivotal role of DCLK1-regulated mechanisms in driving SARS-CoV-2 replication-transcription processes and pathogenic signaling. Notably, pharmacological inhibition of DCLK1 kinase during SARS-CoV-2 effectively impedes these processes and counteracts virus-induced alternations in global cell signaling. These findings hold significant potential for immediate application in treating COVID-19. |
