| Primary Identifier | MGI:7563991 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Mfn2 |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated an A to G change resulting in a methionine to valine substitution at amino acid 376 (p.M376V) in exon 12. A synonymous mutation p.S378 (TCC to TCA) was also introduced to prevent the binding and recutting of the sequence by gRNA. This is a Charcot-Marie-Tooth disease type 2A-associated mutation. |
