Primary Identifier | MGI:6399951 | Allele Type | Targeted |
Gene | Bard1 | Transmission | Germline |
Strain of Origin | (C57BL/6J x 129S6/SvEvTac)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A lysine to alanine missense mutation at amino acid 607 (K607A) was inserted into exon 9 and a loxP-flanked PGK-neomycin resistance gene cassette was inserted into intron 8. The selection cassette was removed via cre-mediated recombination. This mutation corresponds to the human K619A mutation that abrogates BARD1 recognition of PAR. |