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Allele : Bard1<tm2.1Rjbr> BRCA1 associated RING domain 1; targeted mutation 2.1, Richard J Baer

Primary Identifier  MGI:6399951 Allele Type  Targeted
Gene  Bard1 Transmission  Germline
Strain of Origin  (C57BL/6J x 129S6/SvEvTac)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  A lysine to alanine missense mutation at amino acid 607 (K607A) was inserted into exon 9 and a loxP-flanked PGK-neomycin resistance gene cassette was inserted into intron 8. The selection cassette was removed via cre-mediated recombination. This mutation corresponds to the human K619A mutation that abrogates BARD1 recognition of PAR.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Bard1<K607A>,
  • Bard1<K607A>,
  • Bard1<KA>,
  • Bard1<KA>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele