| Help | About | Contact Us

Allele : Dnase1<tm2092.1Arte> deoxyribonuclease I; targeted mutation 2092.1, TaconicArtemis

Primary Identifier	MGI:6400348	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Dnase1
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

Exons 1 to 8 were replaced with a Puromycin selection cassette flanked by F3 sites. Flp-mediated recombination removed the selection cassette. RT-PCR confirmed the absence of the Dnase1 transcript but presence of the overlapping Trap1 transcript.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

earliestPublication:
Kenny EF, et al. (2019) Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease. Eur J Immunol 49(4):590-599

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76678713

MouseMine