| Primary Identifier | MGI:6405195 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Tardbp |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A glycine to serine substitution at amino acid 298 was introduced into exon 6 along with a FRT-flanked neomycin resistance cassette via homologous recombination. Flp-mediated recombination removed the neo selection cassette. The G298S mutation is associated with shorter progression of amyotrophic lateral sclerosis. TARDBP remains nuclear in homozygous mice. |
