| Primary Identifier | MGI:6405407 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Myo7a |
| Transmission | Germline | Strain of Origin | C57BL/6N-A<tm1Brd> |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | EUCOMM |
| molecularNote | Cre-mediated excision of the parental Myo7atm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exons 10-11 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. Western blot analysis confirmed the absence of protein expression in the eye and inner ear. LacZ expresion was not detected. |
