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Allele : Lox<em1Mech> lysyl oxidase; endonuclease-mediated mutation 1, Robert P Mecham

Primary Identifier	MGI:6406219	Allele Type	Endonuclease-mediated
Attribute String	Not Specified	Gene	Lox
Strain of Origin	(C57BL/6J x CBA/J)F2	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR-mediated mutation induced a T to G point mutation that results in the amino acid substitution of arginine for methionine at position 292 (M292R).

mutations:
Single point mutation

synonyms:
Lox p.M292R,
Lox p.M292R,
Lox<Mut>,
Lox<Mut>

earliestPublication:
Lee VS, et al. (2016) Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A 113(31):8759-64

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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