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Allele : Hprt1<tm2(tetO-mediumFT*)Sguo> hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Shangqin Guo

Primary Identifier  MGI:6423503 Allele Type  Targeted
Attribute String  Inducible, Reporter Gene  Hprt1
Transmission  Germline Strain of Origin  129S5/SvEvBrd
Induced With  doxycycline/tetracycline Is Recombinase  false
Is Wild Type  false
description  ES cell line = a mutant A17 line (A2Lox.cre) that carries a doxycycline-inducible Cre recombinase ORF flanked by loxP and lox2272 sites, upstream of a non-functional neomycin resistance (neo) gene.
molecularNote  The tetracycline promoter drives inducible expression along with a ubiquitous CMV of the fluorescent timer protein with the medium mutations (mCherry*M23E, N28D, T48S, K75R, L88W, M155I, Q193L, L204M, Y219C, and R225H) fused to human H2BC9 protein for chromatin localization.
  • mutations:
  • Insertion
  • synonyms:
  • HPRT::iH2B-FT-Medium,
  • Hprt<tm2(tetO/CMV-H2BC9/mediumFT)Sguo>,
  • iH2B-FT-Medium,
  • iH2B-FT-Medium,
  • Hprt<tm2(tetO/CMV-H2BC9/mediumFT)Sguo>,
  • HPRT::iH2B-FT-Medium
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele