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Allele : Shank3<tm2Cmpl> SH3 and multiple ankyrin repeat domains 3; targeted mutation 2, Craig M Powell
Primary Identifier  MGI:6437927 Allele Type  Targeted
Attribute String  Conditional ready, Modified isoform(s) Gene  Shank3
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance and transcriptional STOP cassette flanked by loxP sites was inserted in intron 12 (upstream of the PDZ domain-coding exons). RT-PCR confirmed loss of mRNA expression containing exons 13-19 in the brain. Western blot analysis indicates loss of the two highest molecular weight isoforms.
  • mutations:
  • Insertion
  • synonyms:
  • Shank3<E13>,
  • Shank3<E13>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

5 Publication categories





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