| Primary Identifier | MGI:6429892 | Allele Type | Endonuclease-mediated |
| Attribute String | Hypomorph | Gene | Gtf2ird1 |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 endonuclease-mediated genome editing was used to create a 1 bp adenine insertion in exon 3 of the gene. The deletion causes a frameshift mutation that introduces a premature stop codon. The resulting N-truncated protein has diminished binding capacity. There is a 40% reduction of protein in homozygotes. |
