| First Author | Ni Q | Year | 2017 |
| Journal | FEBS Lett | Volume | 591 |
| Issue | 13 | Pages | 1947-1957 |
| PubMed ID | 28547778 | Mgi Jnum | J:244892 |
| Mgi Id | MGI:5913671 | Doi | 10.1002/1873-3468.12689 |
| Citation | Ni Q, et al. (2017) Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. FEBS Lett 591(13):1947-1957 |
| abstractText | Hepatocyte nuclear factor 1alpha (HNF1alpha) is a liver-enriched transcription factor that is critical for the maintenance of hepatocyte function. Our previous studies have demonstrated the therapeutic effects of HNF1alpha on hepatic fibrosis and hepatocellular carcinoma (HCC) in animals. In this study, we created hepatocyte-specific Hnf1alpha knockout mice using the Cre-loxP recombination system. The knockout mice display increased fatty acid synthesis in the liver. Moreover, these mice spontaneously develop HCC through fatty liver without cirrhosis. Inflammatory cytokines, such as tumor necrosis factor alpha and IL-6, are upregulated and accompanied by increased phosphorylation of Akt, p-65 and STAT3 in the livers of HNF1alpha knockout mice. Our findings suggest that HNF1alpha plays a crucial role in hepatocyte lipid metabolism and hepatocarcinogenesis. |
