Primary Identifier | MGI:6414871 | Allele Type | Endonuclease-mediated |
Gene | Wnk4 | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | CRISPR-Cas9 technology generated a CTC to TTC change resulting in a leucine to phenylalanine substitution at amino acid 319 and a CTG to TTC change resulting in a leucine to phenylalanine substitution at amino acid 321. The L319F/L321F mutations result in a chloride-insensitive WNK4. |