Primary Identifier | MGI:6431142 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Myo6 |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 technology generated a G to A change at position 1325 resulting in a cysteine to tyrosine substitution at residue 442 in exon 13. The C442Y missense variant is seen in patients with autosomal dominant nonsyndromic hearing loss. |