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Allele : Myo6<em1Bcgen> myosin VI; endonuclease-mediated mutation 1, Biocytogen LLC

Primary Identifier  MGI:6431142 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Myo6
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a G to A change at position 1325 resulting in a cysteine to tyrosine substitution at residue 442 in exon 13. The C442Y missense variant is seen in patients with autosomal dominant nonsyndromic hearing loss.
  • mutations:
  • Single point mutation
  • synonyms:
  • Myo6-C442Y,
  • Myo6-C442Y
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele