| First Author | Gurumurthy CB | Year | 2020 |
| Journal | Nat Protoc | Volume | 15 |
| Issue | 12 | Pages | 3777-3787 |
| PubMed ID | 33106680 | Mgi Jnum | J:298750 |
| Mgi Id | MGI:6488455 | Doi | 10.1038/s41596-020-00403-2 |
| Citation | Gurumurthy CB, et al. (2020) Genetically modified mouse models to help fight COVID-19. Nat Protoc 15(12):3777-3787 |
| abstractText | The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19). One major challenge in achieving these goals is the paucity of suitable preclinical animal models. Mice constitute ~70% of all the laboratory animal species used in biomedical research. Unfortunately, SARS-CoV-2 infects mice only if they have been genetically modified to express human ACE2. The inherent resistance of wild-type mice to SARS-CoV-2, combined with a wealth of genetic tools that are available only for modifying mice, offers a unique opportunity to create a versatile set of genetically engineered mouse models useful for COVID-19 research. We propose three broad categories of these models and more than two dozen designs that may be useful for SARS-CoV-2 research and for fighting COVID-19. |
