| Primary Identifier | MGI:6446110 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Sh2b1 |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 endonuclease-mediated genome editing was used to create an amino acid substitution at position 322 altering proline to serine (P322S; CCC to TCC) in exon 3 of the gene. The mutation is located in the pleckstrin domain (PH), and was identified as a human childhood obesity-associated variant allele. |
