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Allele : Ripk3<em1Hbz> receptor-interacting serine-threonine kinase 3; endonuclease-mediated mutation 1, Haibing Zhang

Primary Identifier	MGI:6449643	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Ripk3
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

A 12-bp deletion (TCCAGTGGGACT) on exon 3 was generated by CRISPR/Cas9 genome editing technology. This deletion results in a four-amino-acid (20QWDF23) deletion in the kinase domain of the encoded protein.

mutations:
Intragenic deletion

synonyms:
Ripk3<delta>,
Ripk3<delta>

earliestPublication:
Zhao Q, et al. (2017) RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice. Cell Rep 19(4):798-808

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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