| First Author | Feng Q | Year | 2020 |
| Journal | Am J Pathol | Volume | 190 |
| Issue | 2 | Pages | 469-483 |
| PubMed ID | 31783009 | Mgi Jnum | J:290087 |
| Mgi Id | MGI:6435269 | Doi | 10.1016/j.ajpath.2019.10.010 |
| Citation | Feng Q, et al. (2020) miR-149* Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression. Am J Pathol 190(2):469-483 |
| abstractText | Liver cancer is the third leading cause of cancer-related death worldwide. Herein, we show that miR-149* serves as a novel tumor suppressor for liver tumorigenesis. Mice with genetic deletion of miR-149* (miR-149*(-/-) mice), which caused loss of both miR-149 and miR-149*, were considerably more susceptible to acute liver injury and hepatic carcinogenesis induced by diethylnitrosamine than wild-type mice, accompanied by increased compensatory proliferation and up-regulated gene expression of certain inflammatory cytokines. miR-149* mimics dramatically impaired liver cancer cell proliferation and migration in vitro and blocked liver cancer progression in a xenograft model. Furthermore, miR-149* strongly suppressed NF-kappaB signaling and repressed tumor necrosis factor receptor type 1-associated death domain protein expression in the NF-kappaB signaling pathway. These results reveal that miR-149*, as a novel liver tumor suppressor, may serve as a potential therapeutic target for liver cancer treatment. |
