| Primary Identifier | MGI:6452200 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Setbp1 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 genome editing is used to insert a S858R point mutation (AGC to AGG on the sense strand) using guide RNA [sense strand; GAGACTATCCCGAGCGACAG] in combination with stranded oligonucleotide donor DNAs [antisense strand; GGAACAGAAGTCGAAAGAGTACCTCCGCCGGGATTCTGAACTCTTCTCTGCTTGGTCGGAGGTGCTGTTGTTGTCTGTCCCGATGCCACTGTCCCTCGGGATAGTCTCCTCGCTGTGGGACTCACTC]. The S858R point mutation associated with Schinzel-Giedion midface retraction syndrome, and Mental retardation, autosomal dominant 29. |
