| Primary Identifier | MGI:6454349 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Chchd10 |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A c.164C>T point mutation changes serine codon 55 (TCA) to leucine codon TTA (p.S55L) in exon 3. This mutation is the equivalent of the p.S59L mutation found in some FTD-ALS (frontotemporal dementia-amyotrophic lateral sclerosis) patients. The self-excising loxP site flanked cre gene neomycin resistance gene cassette that was inserted into intron 3 was removed through cre-mediated recombination in male germinal cells. |
