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Allele : Tg(Thy1/THY1)hT10Gsv transgene insertion hT10, Frank Grosveld

Primary Identifier  MGI:6458481 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Thy1/THY1)hT10Gsv
Strain of Origin  (CBA x C57BL/10)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene is a hybrid Thy1 gene in which a 0.8 kb BstEII-ApaI fragment containing part of exons 3 and 4 of the mouse gene was replaced with the homologous 0.96 kb BstEII-ApaI human THY1 gene fragment (containing the mature protein and transmembrane sequences) while the 5' and 3' flanking regions are mouse sequences. High expression of the hybrid transgene is seen in the kidney proximal tubular epithelium and in the brain.
  • mutations:
  • Insertion
  • synonyms:
  • hT10,
  • hT10
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1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories