|  Help  |  About  |  Contact Us

Allele : Tg(Cd3d-Insr*)1Mcin transgene insertion 1, Marcia McInerney
Primary Identifier  MGI:6478197 Allele Type  Transgenic
Attribute String  Epitope tag, Inserted expressed sequence Gene  Tg(Cd3d-Insr*)1Mcin
Strain of Origin  C57BL/6NTac Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene insert encodes a full-length mouse insulin receptor protein cDNA containing an N-terminal 3xFLAG (DYKDDDDK) tagged alpha-subunit and full length beta-subunit as seen in the native mouse Insr gene. The endogenous signal peptide coding sequence was deleted and replaced with a pre-protrypsin (PPT) signal peptide. Thetransgene is placed downstream of the mouse Cd3d enhancer and promoter construct to elicit T-lymphocyte directed transgene over-expression. A human growth hormone (hGH) poly A signal enhances mRNA stability
  • mutations:
  • Insertion
  • synonyms:
  • CD3-3×FLAG-mIR/MFM,
  • CD3-3×FLAG-mIR/MFM
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

1 Driven By

5 Publication categories





MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom