| Primary Identifier | MGI:6504904 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Ppp2r2b |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The N-terminal 24 aa (exon 1) of Ppp2r2b have been replaced with the coding sequence for beta-gal (lacZ) and a neomycin cassette surrounded by two loxP sites followed by a polyadenylation signal to terminate the transcript. A correctly targeted mouse was crossed with a Cre deleter mouse to remove the neomycin cassette. The allele is a null allele. Loss of protain product was confirmed by Western blotting PP2A holoenzymes purified from total forebrain. |
