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Allele : Adora1<em1(cre)Rei> adenosine A1 receptor; endonuclease-mediated mutation 1, Marc L Reitman

Primary Identifier	MGI:6509134	Allele Type	Endonuclease-mediated
Attribute String	Recombinase	Gene	Adora1
Strain of Origin	(C57BL/6 x DBA)F1	Is Recombinase	true
Is Wild Type	false

molecularNote

CRISPR/cas9 genome editing is used to insert a T2A peptide sequence and Cre recombinase at the stop codon. T2A sequence adds EGRGSLLTCGDVEENPG to the C terminus of Adora1 and a proline to the N terminus of cre.

mutations:
Insertion

synonyms:
Adora1-Cre,
Adora1-Cre

earliestPublication:
Province HS, et al. (2020) Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PLoS One 15(12):e0243986

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

1 Driven By

2 Publication categories

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