| Primary Identifier | MGI:6488486 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Aig1 |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9-mediated recombination created a 5 bp deletion (CTGTG) followed by a 1 bp (A) insertion in exon 1 upstream of the catalytic threonine (T43) resulting in a frameshift mutation and premature stop codon upstream of the catalytic threonine. Western blot analysis confirmed the absence of expression in brains from homozygous mice. |
