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Allele : Gab2<tm5.1Thir> growth factor receptor bound protein 2-associated protein 2; targeted mutation 5.1, Toshio Hirano
Primary Identifier  MGI:6477303 Allele Type  Targeted
Gene  Gab2 Transmission  Germline
Strain of Origin  (129 x C57BL/6)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  A cDNA encoding 89-665 amino acids was inserted into exon 2 of Gab2 gene. The cDNAs encoded Y441F/Y465F/Y573F/Y603F/Y632F mutant abolishing the SHP2 and PI3K-binding domains. Cre-mediated recombination removed the selection cassette.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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