| Primary Identifier | MGI:6507747 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Scn1a |
| Strain of Origin | (C57BL/6 x SJL)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A K1259T (nucleotide AAA to ACC) missense mutation that is homologous to the human K1270T mutation was introduced to exon 19 using CRISPR/Cas9 methodologies. A silent EcoRV site mutation used for genotyping was introduced downstream of K1270T, and 2 additional silent insertional mutations flank the K1270T mutation to prevent Cas9 activity on the repaired allele. |
