| Primary Identifier | MGI:6505479 | Allele Type | Targeted |
| Gene | App | Transmission | Germline |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | An AC-to-CT mutation (GT-to-AG on forward strand) was engineered in exon 18, which changes aspartic acid codon 664 to an alanine codon (p.D664A). This mutation prevents cleavage of the encoded peptide at the aspartate residue by caspases or caspase-like proteases. The loxP and FRT site flanked neomycin resistance gene cassette that was inserted downstream of exon 18 was deleted through subsequent flp-mediated recombination. |
