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Allele : C4b<em2Crr> complement C4B (Chido blood group); endonuclease-mediated mutation 2, Michael C Carroll

Primary Identifier	MGI:6505589	Allele Type	Endonuclease-mediated
Attribute String	Humanized sequence	Gene	C4b
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

Using sgRNAs and ssODN templates with CRISPR/Cas9 technology, the gene was changed to make the isotypic region resemble the human C4B gene: endogenous codon sequence for PCPVIH was changed to LSPVLD (p.P1116_C1117delLSins)

mutations:
Nucleotide substitutions

synonyms:
C4B,
C4B

earliestPublication:
Simoni L, et al. (2020) Complement C4A Regulates Autoreactive B Cells in Murine Lupus. Cell Rep 33(5):108330

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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