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Allele : Psen1<tm2.1Bdes> presenilin 1; targeted mutation 2.1, Bart de Strooper

Primary Identifier	MGI:6506066	Allele Type	Targeted
Attribute String	Conditional ready	Gene	Psen1
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was introduced in intron 1 and the second together with a Frt-flanked hygromycin B selection marker cassette was inserted into intron 2. The selection cassette was deleted via FLP-mediated recombination in the germline.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Psen1<f>,
Psen1<f>

earliestPublication:
Habets RA, et al. (2019) Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Sci Transl Med 11(494)

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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