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Allele : Mmachc<em1.1Poche> methylmalonic aciduria cblC type, with homocystinuria; endonuclease-mediated mutation 1.1, Ross Poche

Primary Identifier	MGI:6491443	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Mmachc
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/Cas9 technology was used to insert loxP sites flanking exons 2 to 4. Cre-mediated recombination in the germline deleted exons 2 to 4.

mutations:
Intragenic deletion,
Insertion

synonyms:
Mmachc<delta>,
Mmachc<delta>

earliestPublication:
Chern T, et al. (2020) Mouse models to study the pathophysiology of combined methylmalonic acidemia and homocystinuria, cblC type. Dev Biol 468(1-2):1-13

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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