Primary Identifier | MGI:6510879 | Allele Type | Endonuclease-mediated |
Attribute String | Modified isoform(s) | Gene | Nexn |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A 3 bp region coding for the amino acid residue G645 (equivalent to the human G650) was deleted from the endogenous gene using CRISPR/Cas9 genome editing technology. mRNA levels are normal but protein levels are decreased to 30% of wild-type levels in homozygotes. |