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Allele : Gabrg1<em1Ktka> gamma-aminobutyric acid type A receptor subunit gamma 1; endonuclease-mediated mutation 1, Kristopher T Kahle
Primary Identifier  MGI:6506870 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Gabrg1
Strain of Origin  C57BL/6N Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a single base change resulting in a cysteine to tryptophan conversion at position 188 (C188W) in exon 5. Three additional silent changes were made to disrupt the PAM and prevent retargeting and to generate a diagnostic Pstl site. This is a variant associated with trigeminal neuralgia.
  • mutations:
  • Single point mutation
  • synonyms:
  • Cys188Trp,
  • Cys188Trp
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

3 Publication categories





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