| Primary Identifier | MGI:6715980 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Il11 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 was targeted with sgRNAs using CRISPR/Cas9 technology by micro-injecting a plasmid coding for two gRNAs and a Fok1-dCas9 fusion gene (restriction enzyme FokI and nuclease-deficient Cas9) into fertilized oocyte pronuclei. This resulted in a variety of deleterious deletions, insertions and substitutions among founder mice. |
